In the second group of the play-off draw, PAOK have been placed along with also seeded AFC Ajax, BSC Young Boys, R. Standard de Liège and AS Saint-Étienne. These teams will be drawn against one of the following: Qarabağ FK (Azerbaijan), Molde FK (Norway), FK Jablonec (Czech Republic), Brøndby IF (Denmark) or FC Milsami Orhei (Moldova).

The draw groups are as follows:

Group 1
Seeded: Athletic Club (Spain), FC Viktoria Plzeň (Czech Republic), FC Steaua Bucureşti (Romania), Legia Warszawa (Poland), CS Os Belenenses (Portugal).
Unseeded: Rosenborg BK (Norway), FC Zorya Luhansk (Ukraine), MŠK Žilina (Slovakia), FK Vojvodina (Serbia), SCR Altach (Austria).

Group 2
Seeded: AFC Ajax (Netherlands), PΑΟΚ (Greece), BSC Young Boys (Switzerland), R. Standard de Liège (Belgium), AS Saint-Étienne (France).
Unseeded: Qarabağ FK (Azerbaijan), Molde FK (Norway), FK Jablonec (Czech Republic), Brøndby IF (Denmark), FC Milsami Orhei (Moldova).

Group 3
Seeded: FC Rubin Kazan (Russia), FC Salzburg (Austria), Fenerbahçe SK (Turkey), FC Girondins de Bordeaux (France), KKS Lech Poznań (Poland), FC Slovan Liberec (Czech Republic).
Unseeded: HNK Hajduk Split (Croatia), Atromitos (Greece), FC Dinamo Minsk (Belarus), Videoton FC (Hungary), FK Rabotnicki (FYROM), FC Kairat Almaty (Kazakhstan).

Group 4
Seeded: Borussia Dortmund (Germany), AZ Alkmaar (Netherlands), AC Sparta Praha (Czech Republic), Panathinaikos FC (Greece), Southampton FC (England), FC Krasnodar (Russia).
Unseeded: HJK Helsinki (Finland), FC Thun (Switzerland), FC Astra Giurgiu (Romania), FC Midtjylland (Denmark), Odds BK (Norway), Qäbälä FK (Azerbaijan).