Antonis Tsiftsis , born in Giannitsa on July 21, 1999, attracted attention from an early age at the Athletic Academy Giannitsa and Asteras Tripolis academies. The Greek goalkeeper made his professional debut in a 4–0 home win against Platanias on 2 April 2018. Since then, Tsiftsis has made 54 appearances and kept 18 clean sheets for the Arcadians.

He has played for the Greece Under-17 and Under-18 national youth teams four times, keeping two clean sheets, while in July 2023, he was loaned out to Rakov, returning to Asteras in January 2024.